Funded Projects

FRRB firmly believes that a fairer and more inclusive future is built through knowledge and innovation. As stated in the foreword to the document Personalized Medicine – Development Potential of Precision Medicine in the Lombardy Region, “We cannot hope for a fair and inclusive future if we do not understand that, to achieve it, we must increasingly focus on the knowledge society.”

FRRB’s mission is to support and promote research and innovation in the biomedical field at regional, national, and international levels. We do this by funding original and innovative research projects, with the goal of improving citizens’ quality of life and strengthening the Lombardy Healthcare System.

Investing in knowledge and research is the path toward a fairer and more sustainable tomorrow for all.

Since 2015, FRRB has funded biomedical research projects selected through competitive procedures, participating in regional and European calls as a funding body.

The calls issued by FRRB finance projects that help to better understand specific diseases, describe their natural history, identify risk factors and biological mechanisms, and assess the safety and effectiveness of healthcare interventions (drugs, medical devices, vaccines, surgical procedures, and therapies). In recent years, attention has increasingly shifted toward initiatives aimed at improving diagnosis and prevention—for example, through the development of diagnostic tests, biomarkers, or screening algorithms—promoting the rapid introduction of innovative treatments and the phasing out of obsolete or ineffective practices.

As shown in the graph below, the research areas covered by FRRB funding are diverse, in order to address all the needs and demands of the Lombardy region.

TRANSCAN 3 - Bando 2021
PROGETTO PIXEL
Profiling and functional analysis of the Immune environment of eXtramedullary leukemia rELapses
Vedi Dettaglio
PROGETTO LIPIDMAC
Exploiting lipid-laden macrophages to overcome resistance to cancer immunotherapy
Vedi Dettaglio
Bando UNMET MEDICAL NEEDS
Progetto BOOST
Progetto FRRB 3438840 - Bottom-up and tOp-down neuromOdulation of motor plaSTicity in cerebral palsy
Vedi Dettaglio
Progetto Linking Park
Progetto FRRB 3433068 - Linking inflammation to progression of neurodegeneration in Parkinson's disease
Vedi Dettaglio
Progetto IN SIGNO
Progetto FRRB 3423223 - Identification of Novel molecules Supporting the Impact of ß-lactams against clinically-relevant Gram-Negative multidrug resistant Organisms
Vedi Dettaglio
Progetto MATRIx
Progetto FRRB 3440227 - Mesenchymal stromal cells for curing traumatic brain injury
Vedi Dettaglio
Progetto AMPROject
Progetto FRRB 3414083 - AntiMicrobial Peptides-enriched silk fibroin scaffolds: a new strategy to boost the efficacy of conventional antibiotics in antimicrobial Resistance Orthopedic infections
Vedi Dettaglio
Progetto Drop by drop
Progetto FRRB 3441133 - Deciphering the molecular signature in Kleefstra syndrome: proof of principle working model for chromatinopathies
Vedi Dettaglio
Progetto AI-CORPS
Progetto FRRB 3432721 - Trustworthy, integrated Artificial Intelligence tools for predicting high-risk CORonary PlaqueS
Vedi Dettaglio
Progetto TechNoPAIN
Progetto FRRB 3440110 - A new digital technology-based treatment for chronic pain combining neuromodulation, computer-assisted training and telemonitoring
Vedi Dettaglio
Progetto THYMALL
Progetto FRRB 3439334 - Epigenetic modifiers of the GTF2I axis in thymomas and acute lymphoblastic leukemias: a new repurposing paradigm across rare tumors
Vedi Dettaglio
Progetto Remodel
Progetto FRRB 3444218 - Multiomics pRofiling of patient spEcific Models to predict druggable targets in severe neuromuscular rare diseases
Vedi Dettaglio
Progetto INDAGA
Progetto FRRB 3438215 - In depth analysis of salivary gland cancers: from cell lines and genomic evaluation towards clinical trials in locally advanced and recurrent/metastatic disease
Vedi Dettaglio
Progetto MAINSTREAM
Progetto FRRB 3430931 - A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia
Vedi Dettaglio
Progetto NeoPeSino
Progetto FRRB 3421802 - Neoadjuvant pembrolizumab plus chemotherapy in locally advanced sinonasal carcinoma
Vedi Dettaglio
ERAPerMed - Bando 2021
PROGETTO CORSAI
Raman analysis of saliva from COPD patients as new biomarker: AI-based point-of-care for the disease monitoring and management
Vedi Dettaglio
PROGETTO PERCARD
Personalised Prognostics and Diagnostics for Improved Decision Support in Cardiovascular Diseases
Vedi Dettaglio
PROGETTO IMAGENE
Epigenomic and machine learning models to predict pancreatic cancer: development of a new algorithm to integrate clinical, omics, DNA methylation biomarkers and environmental data for early detection of pancreatic cancer in high-risk individuals.
Vedi Dettaglio
PROGETTO SYMMETRY
Subclonal heterogeneitY and MicroenvironMEntal engagement as predictors for Treatment Resistance in lYmphoma
Vedi Dettaglio
ERAPerMed - Bando 2022
Progetto BIPCOM
Medical comorbidities in bipolar disorder: clinical validation of risk factors and biomarkers to improve prevention and treatment
Vedi Dettaglio
Progetto DEEPEN-iRBD
Prodromal DEtErminants for PhENoconversion of idiopathic RBD to alpha-synucleinopathies (PD, DLB and MSA)
Vedi Dettaglio
Progetto ONAKI-ICI
Towards a personalised clinical management of oncologic patients with acute kidney injury associated to immunecheckpoint inhibitors
Vedi Dettaglio
Progetto MG-PerMed
Personalising myasthenia gravis medicine: from “onefits- all” to patient-specific immunosuppression
Vedi Dettaglio
Progetto Stracyfic
Patient Stratification by Standardization of the Image based Sweat Test for Cystic Fibrosis for use in Clinical Routine
Vedi Dettaglio
FRRB SEAL OF EXCELLENCE
PROGETTO AUTISMI
Progetto FRRB 2679742 - Role of the Gut Vascular Barrier and Microbiota in Autism Spectrum Disorders
Vedi Dettaglio
PROGETTO APRECOT
Progetto FRRB 2681424 - Assessment of Predictors of Response to Cognitive Training in Patients with First Episode Psychosis.
Vedi Dettaglio
PROGETTO SC_HGSOC
Progetto FRRB 2729068 - Identification of druggable targets using single cell characterisation of epigenetic dysregulation in high-grade serous ovarian cancer.
Vedi Dettaglio
PROGETTO MICBIORADIO
Progetto FRRB 2721017 - Discovering the MicroBiota potential for personalised Radiotherapy
Vedi Dettaglio
PROGETTO DELIVER
Progetto FRRB 3269225 - Towards systematic characterisation of gene functions in adult organs: development of a liver-based in vivo essentiality screen
Vedi Dettaglio
EJP Rare Diseases - Bando 2020
PROGETTO SILENCE-LQTS
SGK1 inhibition as a novel therapeutic approach in Long QT syndrome
Vedi Dettaglio
PROGETTO SCN1A-UP!
Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of pathological remodeling
Vedi Dettaglio
PROGETTO TREAT-SGS
Development and preclinical testing in human cell models and transgenic mice of a novel treatment for Schinzel-Giedion Syndrome
Vedi Dettaglio
FRRB Early Career Award
PROGETTO VASCO
Progetto FRRB 1739635 - Functional and structural cerebrovascular alterations in neurological disorders: the role of complement
Vedi Dettaglio
PROGETTO MuST-AS
Progetto FRRB 1734478 - Multiple sclerosis: translating alternative splicing events into therapeutic targets and biomarkers.
Vedi Dettaglio
PROGETTO GenTooControl
Progetto FRRB 1751658 - Leveraging gene-based tools to control local and systemic circuits of tumor tolerance.
Vedi Dettaglio
PROGETTO PANTHER
Progetto FRRB 1740526 - Precision Medicine Applied to Leigh Syndrome at different stages: development of a Neonatal metabolic supplementation and a fetal gene THERapy approach.
Vedi Dettaglio
PROGETTO UNEARTH
Progetto FRRB 1745126 - A thorough understanding of the molecular players causing rare complement-mediated glomerular diseases toward a personalized therapy.
Vedi Dettaglio
PROGETTO MODEL-MS-AGING
Progetto FRRB 1750327 - Personalized brain organoid model of premature aging in multiple sclerosis.
Vedi Dettaglio
PROGETTO ClulnhForPD
Progetto FRRB 1737591 - Exploring LRRK2-Clusterin pathway as a therapeutic strategy for Parkinson’s disease.
Vedi Dettaglio
PROGETTO GWAS-ATTR
Progetto FRRB 1751723 - Genetic modifiers of hereditary and acquired ATTR amyloidosis.
Vedi Dettaglio
PROGETTO PEPTIDE
Progetto FRRB 1737173 - PLA2R-autoreactivE B-cell subsets in membranous nePhropaThy: Identification of outcome predictors and novel insights into Disease pathogenesis
Vedi Dettaglio
PROGETTO CONNECTION
Progetto FRRB 1731651 - Chnndroitin sulfate proteoglycan-4, secreted by a binding imbalance between SP1 and NF-kB on CHST11 gene, triggers sympathetic cardiac denervation in Duchenne Muscular Dystrophy.
Vedi Dettaglio
PROGETTO NeOsReDy
Progetto FRRB 1751150 - Restoring neural oscillatory communication between dorsal and ventral visual streams in developmental dyslexia
Vedi Dettaglio
PROGETTO #METOOLIPO
Progetto FRRB 1751036 - Precision medicine tools to advance management of liposarcoma patients.
Vedi Dettaglio
PROGETTO VITA for NAFLD
Progetto FRRB 1749055 - A very innovative therapeutic approach for non-alcoholic fatty liver disease and its complications
Vedi Dettaglio
PROGETTO InflammaPark
Progetto FRRB 1750818 - Decoding the molecular basis of the interplay between neuroinflammation and neurodegeneration in Parkinson’s disease.
Vedi Dettaglio
PROGETTO CTC Mining
ProgettoFRRB 1731093 - Interrogating circulating lung tumor cells to guide personalized therapies and identify novel targets to hit metastasis initiating cells.
Vedi Dettaglio
PROGETTO PRESENT
Progetto FRRB 1749118 - Exposures to PRenatal and postnatal adverse stressful Experiences: Multimodal omics signatures underlying Stress vulnerability and resilience and as Novel Targets for preventive strategies.
Vedi Dettaglio
FRRB Early Career Award II edizione
PROGETTO AIVAR
Progetto FRRB ID 4981942 - Artificial Intelligence-Enhanced Diagnosis of PBC-AIH Variant Syndrome (AIVAR)
Vedi Dettaglio
PROGETTO CANLAB
Progetto FRRB ID 4986890 - Conformational Antibodies and Neuromuscular disorders and: LABoratory diagnostic and novel targets (CANLAB)
Vedi Dettaglio
PROGETTO cHSPC-GT
Progetto FRRB ID 4977394- Circulating hematopoietic stem cells as innovative target for gene therapy (cHSPC-GT)
Vedi Dettaglio
PROGETTO CILIA
Progetto FRRB ID 4976687- Cholangioids to dissect the genetic drivers of atypical Primary Sclerosing Cholangitis (CILIA)
Vedi Dettaglio
PROGETTO EPIC-BAP
Progetto FRRB ID Unlocking Precision Therapies: Epigenetic Control in BAP1-Mutated Tumors (EPIC-BAP)
Vedi Dettaglio
PROGETTO FORECAST
Progetto FRRB ID 4980460 - FluidOdynamics and plaque moRphology integrated assEssment to prediCt coronAry inStabiliTy (FORECAST)
Vedi Dettaglio
PROGETTO FUN AT PLAQUE
Progetto FRRB ID 4962566-Ficolin-2-dependent mechanisms of morpho-functional evolution of unstable atherosclerotic plaques (FUN AT PLAQUE)
Vedi Dettaglio
PROGETTO GEAM
Progetto FRRB ID 4977360 - Yield of GEnetic testing in Arrhythmic Myocarditis (GEAM)
Vedi Dettaglio
PROGETTO GENETICA
Progetto FRRB 4980634 - Evaluation of genetic-molecular causes of Out-ofHospital Cardiac Arrest: from patients to families (GENETICA)
Vedi Dettaglio
PROGETTO LRRKINGTAUOPATHY
Progetto FRRB ID 4969084- Dissect the interplay between LRRK2 and tau: implications for Alzheimer's disease (LRRKingTauopathy)
Vedi Dettaglio
PROGETTO LONELYALS
Progetto FRRB ID 4990089 - LONgitudinal and integrated Evaluation of biomarkers in reLation to phenotYpe in ALS (LONELYALS)
Vedi Dettaglio
PROGETTO MINERVA
Progetto FRRB ID 4984182 - Novel Method for diagnosis of neurodegenerative diseases based on saliva biochemical profiling (MINERVA)
Vedi Dettaglio
PROGETTO MITOGEN-GBA
Progetto FRRB ID 4986772- Effect of sex and GBA interaction on oxidative stress in shaping pd pathology: a multimodal study (MITOGEN-GBA)
Vedi Dettaglio
PROGETTO MULTIFSGS
Progetto FRRB ID 4972567 Multitarget therapy for primary podocytopathies with focal segmental glomerulosclerosis (MULTIFSGS)
Vedi Dettaglio
PROGETTO MULTITREATALS
Progetto FRRB ID 4959813-A multisystem and multitarget therapeutic approach to hamper Amyotrophic Lateral Sclerosis (MULTITREATALS)
Vedi Dettaglio
PROGETTO OMNISAFE
Progetto FRRB ID 4987503 - OMics-based newborn integrated screening for accurate false-positive easing: discovery of new signatures with an artificial intelligence approach (OMNISAFE)
Vedi Dettaglio
PROGETTO RE-WALK-EASY
Progetto FRRB 4969414 - Regaining walking ability easier and better in critical illness polyneuropathy and myopathy (RE WALK EASY)
Vedi Dettaglio
PROGETTO SACS
Progetto FRRB 4969522 - Role of SGLT-2 in the systemic manifestations of ANCA-associated vasculitis (SACS)
Vedi Dettaglio
PROGETTO SPRINT-PD
Progetto FRRB ID 4981375 - Somatic recombination and inflammatory signatures for Parkinson's disease diagnosis and treatment (SPRINT-PD)
Vedi Dettaglio
PROGETTO SMA-TCHING
Progetto FRRB ID 4956734 - Spinal muscular atrophy translating customized health innovations to newborn and grown-up patients (SMA-TCHING)
Vedi Dettaglio
PROGETTO TARGET-TFR2
Progetto FRRB ID 4976651 -Identification of new strategies for in vivo targeting of erythroid Tfr2 in ß-thalassemia (TARGET-TFR2)
Vedi Dettaglio
PROGETTO THE FAMILY STUDY
Progetto FRRB ID 4957922- High-risk coronary atherosclerosis in subjects with family history of myocardial infarction (THE FAMILY STUDY)
Vedi Dettaglio
ERAPerMed - Bando 2020
PROGETTO DECODE
Defining stratification of patients with C3 Glomerulopathies/immune complex-mediated glomerular diseases for better diagnosis and tailored treatment.
Vedi Dettaglio
PROGETTO HIRISK-HIGAIN
Rethinking personalized cancer therapy: targeting minimal residual disease in high-risk lymphoma patients
Vedi Dettaglio
PROGETTO PERPLANRT
Personalized Planning in Radio Therapy Through Integrative Modeling of Local Dose Effect and New Dosimetric Constraints
Vedi Dettaglio
PROGETTO PRESERVE
AI for new signatures and models for tailored organ preservation approaches in laryngeal and hypopharyngeal cancer.
Vedi Dettaglio
PROGETTO EV-GLIO
Plasma extracellular vesicles (EVs): the key for precision medicine in Glioblastoma
Vedi Dettaglio
ERAPerMed - Bando 2019
PROGETTO SuPerTreat
Supporting Personalized Treatment Decisions in Head and Neck Cancer through Big Data.
Vedi Dettaglio
PROGETTO PerBrain
A Multimodal Approach to Personalized Tracking of Evolving State-Of-Consciousness in Brain- Injured Patients.
Vedi Dettaglio
PROGETTO Serpentine
Quantifying systemic immunosuppression to personalize cancer therapy.
Vedi Dettaglio
EJP Rare Diseases - Bando 2019
PROGETTO PROGERIA
The rarest of the rare – exploring non-coding RNA in the disease pathogenesis of Hutchinson-Gilford progeria syndrome.
Vedi Dettaglio
PROGETTO DevDBA
Ontogeny as a critical determinant of DBA sensitivity in red blood cell.
Vedi Dettaglio
PROGETTO LQTS-NEXT
LQTS-NEXT: to the NEXT level of risk prediction in patients with Long QTS Syndrome
Vedi Dettaglio
Bando 2018 - Progetti di Rete - II edizione
PROGETTO INTESTRAT-CAD
A prospective clinical study integrating multiomics and advance coronary imaging for risk stratification in coronary atherosclerosis.
Vedi Dettaglio
PROGETTO CARE4NEURORARE
An integrated omics approach for patients with rare neurological disorders: towards personalized clinical care and trial readiness.
Vedi Dettaglio
PROGETTO IANG-CRC
A regional oncology network addressing the emerging problem of colorectal cancer in young individuals using an integrative omics approach to decipher mechanisms of cancer immunoediting as candidate targets of new therapies.
Vedi Dettaglio
PROGETTO NEVERMIND
New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.
Vedi Dettaglio
PROGETTO PLAGENCELL
A network for cell and gene therapies for devastating diseases.
Vedi Dettaglio
Bando speciale 2018 - Malattie Amianto-Correlate
PROGETTO PRIMATE
An integrated precision medicine approach to malignant mesothelioma: from mutation load to epidemiology and therapy
Vedi Dettaglio
ERAPerMed - Bando 2018
PROGETTO RADPrecise
Personalized radiotherapy: incorporating cellular response to irradiation in personalized treatment planning to minimize radiation toxicity
Vedi Dettaglio
PROGETTO LVADStrat
Stratification of heart failure patients for cardiac recovery upon cardiac unloading by left ventricular assist device therapy: addressing the molecular, epigenetic, and proteomic changes associated with reverse cardiac remodelling.
Vedi Dettaglio
PROGETTO FindingMS
An integrated approach to predict disease activity in the early phases of Multiple Sclerosis
Vedi Dettaglio
PROGETTO BATMAN
Biomolecular Analyses for Tailored Medicine in Acne iNversa
Vedi Dettaglio
TRANSCAN 2 – Bando 2017 – Translational research on rare cancers.
PROGETTO QUANT-ALL
Automated, absolute quantification of MRD in ALL patients by droplet microfluidics, single DNA copy barcoding and IG/TR amplicon NGS
Vedi Dettaglio
TRANSCAN 2 – Bando 2016 - Minimally and non-invasive methods for early detection and/or progression of cancer.
PROGETTO TRANSCALL-2
Integration of genetic biomarkers and early Minimal Residual Disease to improve risk stratification and cure in childhood Acute Lymphoblastic Leukemia
Vedi Dettaglio
PROGETTO SCRATCH
Microbiota-based screening of anal cancer in HIV-infected individuals
Vedi Dettaglio
PROGETTO IMMUNOCELL
Single-cell immunophenotypic and transcriptomic profiling for minimally-invasive detection of early multiple myeloma
Vedi Dettaglio
Bando 2015 - Strategia per la Valorizzazione della Ricerca Biomedica
PROGETTO TRANS-ALS
FRRB 2015-023 - Translating molecular mechanisms into ALS risk and patient’s well-being (TRANS-ALS)
Vedi Dettaglio
PROGETTO REL
FRRB 2015-042 - Genomic profiling of rare hematologic malignancies, development of personalized medicine strategies, and their implementation into the Rete Ematologica Lombarda (REL) clinical network
Vedi Dettaglio
PROGETTO CMV
FRRB 2015-043 - Pathogenesis and prevention of non primary human cytomegalovirus infection
Vedi Dettaglio
PROGETTO LYRA
FRRB 2015-010 - Single-cell analyses of lymphocytes that infiltrate autoimmunity sites: dissecting immunological mechanisms of rheumatoid arthritis
Vedi Dettaglio
JPI AMR Bando 2022
PROGETTO Acoma
Optimization of Antibiotic Combinations using Organoids for treatment of Mycobacterium abscessus infections
Vedi Dettaglio
PROGETTO Donate
LyophilizeD fecal micrObiome traNsfer for primAry closTridioides difficilE infection (DONATE study): a multicenter randomized controlled trial
Vedi Dettaglio
JPI AMR Bando 2023
PROGETTO Fight AMR
Novel global One Health surveillance approach to fight AMR using Artificial Intelligence and big data mining
Vedi Dettaglio
JPI AMR Bando 2024
PROGETTO Fugaci
Fungal genomics and Antagonistic Community Interactions
Vedi Dettaglio
EJP Rare Diseases Bando 2022
PROGETTO Eureka
Bonding molecular genotyping and phenotyping to outcome measures in AL amyloidosis: A EUropean REgistry and sample sharing networK to promote the diagnosis and management of light chain Amyloidosis
Vedi Dettaglio
PROGETTO Predyt
Predictive biomarkers in dystonia: defining the paradigm of monogenic dystonia to implement the diagnosis and prognosis of undiagnosed forms
Vedi Dettaglio
EJP RD Bando 2023
PROGETTO Precise
Biomarkers and outcome PREdictors of paediatriC nephrotIc syndrome: a genetic, transcriptomic and SEcretome multiomics study
Vedi Dettaglio
TRANSCAN3 Bando 2023
PROGETTO Hydra
Charting the epigenetic trajectory of progression towards metastatic colorectal cancer
Vedi Dettaglio
PROGETTO Dice
Epigenomic ragulation of cancer immunity by dietary intervention
Vedi Dettaglio
TRANSCAN3 Bando 2024
PROGETTO Lungoids
Subtype-specific Lung Cancer Organoids based on artificial ECM for Precision Oncology: Closing the Gap Between Preclinical Models and Patient Care
Vedi Dettaglio
PROGETTO Titan
Novel Cancer Therapy: Inducing Double-strand DNA Breaks to Foster Tumor Cell Death, Antigenicity and Immunotherapy Response in New Personalized Models
Vedi Dettaglio
EP PERMED Bando 2024
PROGETTO Hi-ROC
Targeting Hypoxia with heavy ions to gain control of RadiOresistance Cancers
Vedi Dettaglio
PROGETTO Sei Mito
Speed the Efficacy of Idebenone on MITOchondrial Leber Hereditary Optic Neuropathy (LHON) targeting NQO1
Vedi Dettaglio
PROGETTO 3D Leuko Tad
Topologically Associating Domains (TADs) boundary disruption and 3D genome alterations as targets in acute leukemia therapies
Vedi Dettaglio
TRANSCAN3 Bando 2022
PROGETTO iCC-STRAT
Risk stratification and subtyping of intrahepatic cholangiocarcinoma for early detection of recurrence and response to immuno-therapy
Vedi Dettaglio
PROGETTO TPlex-EAC
T-Plex-Capture: Isolation of neoantigen-specific CD8+ T cell receptors for patient-specific immunotherapy in esophageal adenocarcinoma (EAC)
Vedi Dettaglio
Bando di Ricerca Collaborativa Under 40
GLIDE
Glioblastoma: Leveraging Metabolic Dependencies for Personalized Treatment
Vedi Dettaglio
TACTIC-P
Targeting Tissue-Resident T Cells for Personalized Immunotherapy and Recurrence Prevention in Patients with Node-Positive Prostate Cancer undergoing PSMA-guided Surgery
Vedi Dettaglio
I-BREAKFAST-2
Comprehensive Immunometabolic profiling of TNBC patients receiving chemoimmunotherapy plus/minus calorie restriction in the BREAKFAST2 trial
Vedi Dettaglio
BRAVE
Next-Generation Anti-Biofilm Strategies:Bacterial Extracellular Vesicles as Diagnostic and Therapeutic Tools to Overcome Antibiotic Resistance in Prosthetic Infections
Vedi Dettaglio
CART-SEN
Longitudinal tracking of CAR-T cell clonotypes and evaluation of CAR-T cell senescence in patients affected by B-cell malignancies
Vedi Dettaglio
PAVE
Personalized Aortic Valve Engineering to tackle fibro-calcific progression
Vedi Dettaglio
BINGO
MicroBiome-Driven Immunosuppression: Unlocking New Strategies for TNBC Treatment
Vedi Dettaglio
NEO-DARK
Unmasking Dark Neoantigens in Early-Onset Colorectal Cancer as a Novel Frontier for Cancer Immunotherapy
Vedi Dettaglio
REACT
Developing a Region-Wide Machine-Learning–Empowered Platform for Actionable Genomic Epidemiology of Antimicrobial-Resistant Bacterial Clones
Vedi Dettaglio
EPIMAI
Early and Precise Identification of brain MRI abnormalities in pediatric epilepsy through Artificial Intelligence
Vedi Dettaglio
PANORAMA
From PAtients to Neuromuscular Organoids in Refractory AChR+ Myasthenia grAvis: end-plate dysfunction, biomarker discovery and regeneration strategies
Vedi Dettaglio
DIOGENE
Development of multiple bioprinted Inflammatory eye models to study dry eye and Ocular Graft vs host disease (oGVHD) integrating tissue ENgineering for Enhanced research and therapies
Vedi Dettaglio
SarcUS-PIBD
Ultrasound Assessment of Sarcopenia in Pediatric Inflammatory Bowel Disease: A Prospective Validation Study
Vedi Dettaglio
REBORN
Regeneration of Esophageal tissue with BiOengineeRed Neovascularized scaffold
Vedi Dettaglio
VISTE
Vascular Insights into Sarcoma Treatment with Eribulin "VISTE" study, a Comprehensive Spatial and Functional Analysis of Eribulin-Induced Vasculature Remodeling in Sarcoma
Vedi Dettaglio
RADARR
Unraveling the Role of RAD51 in PARPi Resistance: From Molecular Insights to Therapeutic Strategies for Advanced Ovarian Carcinoma
Vedi Dettaglio
IDEA PROJECT
Investigating determinants of immunotherapy efficacy in endometrial cancer: a multidimensional approach in a unique population
Vedi Dettaglio
IL-1R8CHEMOBEAT
Characterization of IL-1R8 as a Novel Immune Checkpoint to Boost Chemotherapy and Mitigate Cardiotoxicity
Vedi Dettaglio
FRRB/FONDAZIONE TELETHON: MULTI-ROUND CALL FOR RESEARCH PROJECTS 2025 – 2027 – ROUND I
Ribosomal pathologies: mechanistic therapy of Shwachman-Diamond syndrome
Vedi Dettaglio
Synaptic dysfunction in Angelman syndrome: spatio-temporal trajectories and molecular mechanisms
Vedi Dettaglio
Therapeutic approaches in spinal bulbar muscular atrophy (SBMA): exploiting the alternative AR-A isoform to mitigate the toxicity of the mutant androgen receptor that drives the disease
Vedi Dettaglio
Addressing the metabolic and functional defects in neurons and oligodendrocytes in nasu hakola disease
Vedi Dettaglio
Decoding disease diversity: the impact of missense mutations on FLVCR1 isoforms and their interaction networks.
Vedi Dettaglio
Evaluating the Safety and Efficacy of ASO-Based Therapy in the Murine Model of Schinzel-Giedion Syndrome
Vedi Dettaglio
AAV9-mediated gene replacement strategy for the treatment of Charcot-Marie-Tooth type 4B1 and B2 neuropathies with aberrant myelin
Vedi Dettaglio
AAV gene therapy for Marinesco-Sjögren syndrome: optimizing delivery, expression and therapeutic timing for clinical translation
Vedi Dettaglio
THCS 2025
CC4C
Closer Care for Children: Transitioning from institutionalized to home and community-based delivery models for pediatric rehabilitation
Vedi Dettaglio
P.R.I.M.E.
Primary Care and Mental Health Ecosystems: Towards Sustainable and Community-Based Care Pathways
Vedi Dettaglio
WISH
Early breast cancer, follow-up, hormonal treatment, drug toxicity, lifestyle intervention, remote patient monitoring, community health service
Vedi Dettaglio
ERDERA 2025
MT2-ASD
Melatonin MT2-Selective Agonists as a Novel Treatment for Fragile X Syndrome (FXS) and Phelan-McDermid Syndrome (PMS)
Vedi Dettaglio
SynLeigh
Towards synergistic treatments for Leigh Syndrome Spectrum disorders
Vedi Dettaglio
T-CARE
T-cell-based Approaches for Controlling Autoimmune disease with Epilepsy
Vedi Dettaglio
EP PerMed 2025
BIOKID-PG
Genomics, metabolomics, transcriptomics, inflammatory bowel disease, pediatrics, anti-TNF drugs, pharmacogenomics
Vedi Dettaglio
IMPACT-CRC
CRC, immunotherapy, multi-omics, bioinformatics/AIML, biomarkers, methodology
Vedi Dettaglio
Optimize
Multiomics signature to customize induction or neoadjuvant treatments for optimizing laryngeal preservation strategies.
Vedi Dettaglio
PRECISION-tMN
Therapy-related myeloid neoplasms (t-MN), Hypomethylating Agents (HMA), Precision medicine, Epigenetics, Multi-omics integration, Patient-derived in vitro testing, in silico modeling.
Vedi Dettaglio
TRANS-AML-EU
Transforming Personalised Acute Myeloid Leukaemia Therapy through an Integrative European Multi-Centre Multi-Omics Network
Vedi Dettaglio
BANDO FROM BED TO BENCH
MIND
Multi-omics prediction modelling of brain metastasis management in breast cancer
Vedi Dettaglio
Glio-SCREEN
Advancing Glioblastoma Treatment: the combination of Omics, Drug Screening, Liquid Biopsy, and artificial intelligence for precision oncology
Vedi Dettaglio
OPTIMAL
Optimizing precision T-cell redirecting therapies in refractory/relapsed large-B cell lymphoma
Vedi Dettaglio
ECLIPSE
Epigenetic changes in long COVID patients: unravelling the gutimmune axis and therapeutic targets
Vedi Dettaglio
EV-PREDICT
Extracellular vesicle-based molecular signatures for personalizing neoadjuvant treatment in triple negative breast cancer
Vedi Dettaglio
PREDICT
Predictive response and disease evolution in ovarian cancer with generative AI
Vedi Dettaglio
PRECURSOR-HCC
Lipid droplet retention asthe causal driver of progressive steatotic liver disease - hepatocellular carcinoma
Vedi Dettaglio
MEDAL
Diagnosis, pathogenesis and innovative therapiesfor metabolic lysosomal storage diseases with skeletal involvement
Vedi Dettaglio
AI-PARKNET
A personalized model of care for Parkinson disease based on AIinformed multimodal stratification of patients
Vedi Dettaglio
DTPDAC
Deciphering and targeting the immunological niche in PDAC
Vedi Dettaglio
IMPACT-ALL
Innovative strategies for advanced molecular and metabolic targeting of pediatric and adult acute lymphoblastic leukemia to personalized treatments
Vedi Dettaglio