Dati del progetto
|
Principal Investigator |
Dr.ssa Letizia Straniero |
|
Ente ospitante |
IRCCS Istituto Clinico Humanitas |
|
Area Tematica |
Neurologia |
|
Data di inizio Progetto |
01/12/2024 |
|
Data di fine Progetto |
30/11/2027 |
|
Importo assegnato |
500.000,00 € |
|
Tipo Progetto |
Individuale |
PROJECT AIM
Parkinson’s disease etiology is complex and involve different and largely unknown environmental factors and genetics determinates. This challenges early diagnosis that, despite proposed biomarkers, remains elusive. Somatic non-allelic homologous recombination (NAHR), disrupting genetic information or affecting regulatory regions, could contribute to aging and neurodegenerative disorders. This study aims to develop Parkinson’s disease non-invasive diagnostic tools understanding how a chronic disorder affects genomic stability in immune cells. It also explores the inflammation role in Parkinson’s disease, thus potentially leading to novel therapeutic strategies.